منابع مشابه
Chymase: the other ACE?
THE THERAPEUTIC USE OF angiotensin-converting enzyme (ACE) inhibitors has been an integral part of the standard of care for hypertension and related diseases for decades. While the beneficial effects of these drugs are universally appreciated, there are a variety of physiological anomalies that remind us that there is still much to be learned about the mechanisms involved in the observed therap...
متن کاملComputational studies of novel chymase inhibitors against cardiovascular and allergic diseases: mechanism and inhibition.
To provide a new idea for drug design, a computational investigation is performed on chymase and its novel 1,4-diazepane-2,5-diones inhibitors that explores the crucial molecular features contributing to binding specificity. Molecular docking studies of inhibitors within the active site of chymase were carried out to rationalize the inhibitory properties of these compounds and understand their ...
متن کاملChymase Activities and Survival in Endotoxin-Induced Human Chymase Transgenic Mice
We examined the effects of overexpressed human chymase on survival and activity in lipopolysaccharide (LPS)-treated mice. Human chymase transgenic (Tg) and wild-type C57BL/6 (WT) mice were treated with LPS (0.03, 0.1 and 0.3 mg/day; intraperitoneal) for 2 weeks. Treatment with 0.03 mg LPS did not affect survival in either WT or Tg mice. WT mice were not affected by 0.1 mg/day of LPS, whereas 25...
متن کاملBiological Function of Mast Cell Chymase
Chugunova, E., 2004. Biological function of mast cell chymase mMCP-4. In vitro and in vivo studies: a thorny pathway. Doctor's dissertation. ISSN 1401-6257, ISBN 91-576-6680-6 Mast cells (MCs) are key effector cells in various types of inflammatory conditions. The MC secretory granules contain inflammatory mediators such as histamine, heparin proteoglycan (PG), cytokines and various heparin-bin...
متن کاملMast cell chymase in pulmonary hypertension.
Mast cells are known to be involved in various types of tissue remodelling but their role in pulmonary hypertension is still poorly understood. Two subtypes of mast cells have recently been identified by demonstrating one protease, chymase. This enzyme might be implicated in vascular remodelling. The changes in mast cells in lung tissue from three patients with primary or secondary pulmonary hy...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1998
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)31168-0